Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension.
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ABSTRACT:
SUBMITTER: Brash L
PROVIDER: S-EPMC5981010 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension.
Brash Lauren L Barnes Gareth D GD Brewis Melanie J MJ Church A Colin AC Gibbs Simon J SJ Howard Luke S G E LSGE Jayasekera Geeshath G Johnson Martin K MK McGlinchey Neil N Onorato Joelle J Simpson Joanne J Stirrat Colin C Thomson Stephen S Watson Geoffrey G Wilkins Martin R MR Xu Carrie C Welsh David J DJ Newby David E DE Peacock Andrew J AJ
JACC. Basic to translational science 20180328 2
Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr<sup>1</sup>)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr<sup>1</sup>)apelin-13 in ...[more]
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