Increasing the Antimicrobial Activity of Nisin-Based Lantibiotics against Gram-Negative Pathogens.

ABSTRACT: Lantibiotics are ribosomally synthesized and posttranslationally modified antimicrobial compounds containing lanthionine and methyl-lanthionine residues. Nisin, one of the most extensively studied and used lantibiotics, has been shown to display very potent activity against Gram-positive bacteria, and stable resistance is rarely observed. By binding to lipid II and forming pores in the membrane, nisin can cause the efflux of cellular constituents and inhibit cell wall biosynthesis. However, the activity of nisin against Gram-negative bacteria is much lower than that against Gram-positive bacteria, mainly because lipid II is located at the inner membrane, and the rather impermeable outer membrane in Gram-negative bacteria prevents nisin from reaching lipid II. Thus, if the outer membrane-tr

SUBMITTER: Li Q 

PROVIDER: S-EPMC5981070 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature