Distinct Nitrite and Nitric Oxide Physiologies in Escherichia coli and Shewanella oneidensis.

ABSTRACT: Nitrite has been used as a bacteriostatic agent for centuries in food preservation. It is widely accepted that this biologically inert molecule functions indirectly, serving as a stable reservoir of bioactive nitric oxide (NO) and other reactive nitrogen species to impact physiology. As a result, to date, we know surprisingly little about in vivo targets of nitrite. Here, we carry out comparative analyses of nitrite and NO physiology in Escherichia coli and in Shewanella oneidensis, a Gram-negative environmental bacterium renowned for respiratory versatility. These two bacteria differ from each other in many aspects of nitrite and NO physiology, including NO generation, NO degradation, and unexpectedly, their contrary susceptibility to nitrite and NO. In cell extracts of both bacteria, mos

SUBMITTER: Meng Q 

PROVIDER: S-EPMC5981078 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature