Risks of cervical intraepithelial neoplasia grade 3 or invasive cancers in ASCUS women with different management: a population-based cohort study.

ABSTRACT: OBJECTIVE:To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS:Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model. This study was approved by the Research Ethics Committee of the National Taiwan University Hospital and is registered at ClinicalTrials.gov (Identifier: NCT02063152). RESULTS:There were total 69,741 women include

SUBMITTER: Tai YJ 

PROVIDER: S-EPMC5981106 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature