Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

ABSTRACT:

Background

Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in human atherosclerotic plaques.

Aims

To investigate whether the mRNA expression levels of interleukin-18 and interleukin-18-binding protein and interleukin-18 −137 G/C (rs187238) variants are associated with carotid artery stenosis development.

Study design

Case-control study.

Methods

The mRNA expression levels of interleukin-18 and interleukin-18-binding protein and interleukin-18 rs187238 variants were evaluated by quantitative real-time polymerase chain reaction and real-time polymerase chain reaction, respecti

SUBMITTER: Arapi B 

PROVIDER: S-EPMC5981122 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature