Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection.

ABSTRACT: Elizabethkingia anophelis has now emerged as an opportunistic human pathogen. However, its mechanisms of transmission remain unexplained. Comparative genomic (CG) analysis of E. anopheles endophthalmitis strain surprisingly found from an eye infection patient with twenty-five other E. anophelis genomes revealed its potential to participate in horizontal gene transfer. CG analysis revealed that the study isolate has an open pan genome and has undergone extensive gene rearrangements. We demonstrate that the strain is naturally competent, hitherto not reported in any members of Elizabethkingia. Presence of competence related genes, mobile genetic elements, Type IV, VI secretory systems and a unique virulence factor arylsulfatase suggests a different lineage of the strain. Deciphering the geno

SUBMITTER: Bulagonda EP 

PROVIDER: S-EPMC5981450 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature