Engineering thermoresponsive phase separated vesicles formed via emulsion phase transfer as a content-release platform.

ABSTRACT: Giant unilamellar vesicles (GUVs) are a well-established tool for the study of membrane biophysics and are increasingly used as artificial cell models and functional units in biotechnology. This trend is driven by the development of emulsion-based generation methods such as Emulsion Phase Transfer (EPT), which facilitates the encapsulation of almost any water-soluble compounds (including biomolecules) regardless of size or charge, is compatible with droplet microfluidics, and allows GUVs with asymmetric bilayers to be assembled. However, the ability to control the composition of membranes formed via EPT remains an open question; this is key as composition gives rise to an array of biophysical phenomena which can be used to add functionality to membranes. Here, we evaluate the use of

SUBMITTER: Karamdad K 

PROVIDER: S-EPMC5982195 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature