Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment.

ABSTRACT: BACKGROUND:Diabetes and high body-mass index (BMI) are associated with increased risk of several cancers, and are increasing in prevalence in most countries. We estimated the cancer incidence attributable to diabetes and high BMI as individual risk factors and in combination, by country and sex. METHODS:We estimated population attributable fractions for 12 cancers by age and sex for 175 countries in 2012. We defined high BMI as a BMI greater than or equal to 25 kg/m2. We used comprehensive prevalence estimates of diabetes and BMI categories in 2002, assuming a 10-year lag between exposure to diabetes or high BMI and incidence of cancer, combined with relative risks from published estimates, to quantify contribution of diabetes and high BMI to site-specific cancers, individually and combine

SUBMITTER: Pearson-Stuttard J 

PROVIDER: S-EPMC5982644 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature