Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations.

ABSTRACT: Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side effects. The efficacy but also side effects of platinum complexes can be mediated by uptake through plasma membrane transporters. In the kidneys, plasma membrane transporters are involved in their secretion into the urine. Renal secretion is accomplished by uptake from the blood into the proximal tubules cells, followed by excretion into the urine. The uptake process is mediated mainly by organic cation transporters (OCT), which are expressed in the basolateral domain of the plasma membrane facing the blood. The excretion of platinum into the u

SUBMITTER: Hucke A 

PROVIDER: S-EPMC5982655 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature