Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study.

ABSTRACT:

Background

African Americans are at high risk for chronic kidney disease (CKD). Obesity may increase the risk for CKD by exacerbating features of the metabolic syndrome and promoting glomerular hyperfiltration. Whether other factors also affecting these pathways may amplify or mitigate obesity-CKD associations has not been investigated.

Methods

We studied interactions between obesity and these candidate factors in 2043 African Americans without baseline kidney disease enrolled in the Jackson Heart Study. We quantified obesity as body mass index (BMI), sex-normalized waist circumference and visceral adipose volume measured by abdominal computed tomography at an interim study visit. Interactions were hypothesized with (i) metabolic risk factors (dietary quality and physical ac

SUBMITTER: Olivo RE 

PROVIDER: S-EPMC5982718 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature