MIPhy: identify and quantify rapidly evolving members of large gene families.

ABSTRACT: After transitioning to a new environment, species often exhibit rapid phenotypic innovation. One of the fastest mechanisms for this is duplication followed by specialization of existing genes. When this happens to a member of a gene family, it tends to leave a detectable phylogenetic signature of lineage-specific expansions and contractions. These can be identified by analyzing the gene family across several species and identifying patterns of gene duplication and loss that do not correlate with the known relationships between those species. This signature, termed phylogenetic instability, has been previously linked to adaptations that change the way an organism samples and responds to its environment; conversely, low phylogenetic instability has been previously linked to proteins with end

SUBMITTER: Curran DM 

PROVIDER: S-EPMC5983006 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature