Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides.

ABSTRACT:

Background & aims

Many individuals are infected with hepatitis B virus (HBV) worldwide, and this virus is commonly controlled by treatments with interferon (IFN)-alpha and nucleoside analogues (NA). However, the complete elimination of HBV by these treatments is difficult and, thus, the development of new treatments is needed. Host immune responses are closely involved in the elimination of HBV, suggesting the usefulness of immunotherapy. In the present study, we attempted to identify novel cytotoxic T-lymphocyte (CTL) epitopes that are useful for immunotherapy against HBV.

Methods

CTL epitopes were predicted using computer software. Immune responses to each peptide were evaluated by IFN-γ ELISPOT and cytotoxic assays. The relationships between the immune responses to these

SUBMITTER: Yamamiya D 

PROVIDER: S-EPMC5983448 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature