Metabotypes of response to bariatric surgery independent of the magnitude of weight loss.

ABSTRACT:

Objective

Bariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations.

Methods

We used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery.

Results

For the first time, global metabolic changes following bariatric surgery independent of the baseline he

SUBMITTER: Palau-Rodriguez M 

PROVIDER: S-EPMC5983508 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature