The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption.

ABSTRACT: The endogenous opioid system may be involved in the development and maintenance of alcohol use disorder (AUD) and is a target for existing AUD pharmacotherapies. A functional polymorphism of the mu-opioid receptor gene (OPRM1 A118G, rs1799971) may alter the risk of developing AUD. Human laboratory studies have demonstrated that minor allele carriers self-administer more alcohol, show greater sensitivity to alcohol's effects, and exhibit increased alcohol-induced dopamine release. On the other hand, large genome-wide association studies and meta-analyses of candidate gene studies have not found an association between this genotype and alcohol dependence diagnosis. Given this discrepancy, the present study sought to verify whether OPRM1 A118G was associated with alcohol self-administration,

SUBMITTER: Sloan ME 

PROVIDER: S-EPMC5983535 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature