Positive regulation of raphe serotonin neurons by serotonin 2B receptors.

ABSTRACT: Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT_2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT_2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT_2B receptors directly and positively regulate raphe serotonin neuron activity. By ex vivo electrophysiological recordings, we report that stimulation by the 5-HT_2B receptor agonist, BW723C86, increased the firing frequency of serotonin Pet1-positive neurons. Viral overexpression of

SUBMITTER: Belmer A 

PROVIDER: S-EPMC5983540 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature