The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque.

ABSTRACT: Psychiatric disorders, particularly depression and anxiety, are often associated with impaired serotonergic function. However, serotonergic interventions yield inconsistent effects on behavioral impairments. To better understand serotonin's role in these pathologies, we investigated the role of serotonin in a behavior frequently impaired in depression and anxiety, attention. In this study, we used a quantitative, repeated, within-subject, design to test how L-5-hydroxytryptophan (5-HTP), the immediate serotonin precursor, modulates central serotoninergic function and attention in macaques. We observed that intramuscular 5-HTP administration increased cisternal cerebrospinal fluid (CSF) 5-HTP and serotonin. In addition, individuals' baseline looking duration, during saline sessions, predict

SUBMITTER: Weinberg-Wolf H 

PROVIDER: S-EPMC5983545 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature