Inhibition of the CCL5/CCR5 Axis against the Progression of Gastric Cancer.

ABSTRACT: Despite the progress made in molecular and clinical research, patients with advanced-stage gastric cancer (GC) have a bad prognosis and very low survival rates. Furthermore, it is challenging to find the complex molecular mechanisms that are involved in the development of GC, its progression, and its resistance to therapy. The interactions of chemokines, also known as chemotactic cytokines, with their receptors regulate immune and inflammatory responses. However, updated research demonstrates that cancer cells subvert the normal chemokine role, transforming them into fundamental constituents of the tumor microenvironment (TME) with tumor-promoting effects. C-C chemokine ligand 5 (CCL5) is a chemotactic cytokine, and its expression and secretion are regulated in T cells. C-C chemokine recep

SUBMITTER: Aldinucci D 

PROVIDER: S-EPMC5983686 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature