HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development.

ABSTRACT: Keloids occur after failure of the wound healing process; inflammation persists, and various treatments are ineffective. Keloid pathogenesis is still unclear. We have previously analysed the gene expression profiles in keloid tissue and found that HtrA1 was markedly up-regulated in the keloid lesions. HtrA1 is a serine protease suggested to play a role in the pathogenesis of various diseases, including age-related macular degeneration and osteoarthritis, by modulating extracellular matrix or cell surface proteins. We analysed HtrA1 localization and its role in keloid pathogenesis. Thirty keloid patients and twelve unrelated patients were enrolled for in situ hybridization, immunohistochemical, western blot, and cell proliferation analyses. Fibroblast-like cells expressed more HtrA1 in acti

SUBMITTER: Yamawaki S 

PROVIDER: S-EPMC5983720 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature