Magnesium Deprivation Potentiates Human Mesenchymal Stem Cell Transcriptional Remodeling.

ABSTRACT: Magnesium plays a pivotal role in energy metabolism and in the control of cell growth. While magnesium deprivation clearly shapes the behavior of normal and neoplastic cells, little is known on the role of this element in cell differentiation. Here we show that magnesium deficiency increases the transcription of multipotency markers and tissue-specific transcription factors in human adipose-derived mesenchymal stem cells exposed to a mixture of natural molecules, i.e., hyaluronic, butyric and retinoid acids, which tunes differentiation. We also demonstrate that magnesium deficiency accelerates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. We argue that magnesium deprivation generates a stressful condition that modulates stem cell plasticity and differe

SUBMITTER: Sargenti A 

PROVIDER: S-EPMC5983826 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature