Identification of key genes and pathways in regulating immune‑induced diseases of dendritic cells by bioinformatic analysis.

ABSTRACT: Dendritic cells (DCs) serve crucial roles in the activation of the immune response, and imbalance in the activation or inhibition of DCs has been associated with an increased susceptibility to develop immune‑induced diseases. However, the molecular mechanisms of regulating immune‑induced diseases of DCs are not well understood. The aim of the present study was to identify the gene signatures and uncover the potential regulatory mechanisms in DCs. A total of 4 gene expression profiles (GSE52894, GSE72893, GSE75938 and GSE77969) were integrated and analyzed in depth. In total, 241 upregulated genes and 365 downregulated genes were detected. Gene ontology and pathway enrichment analysis showed that the differentially expressed genes (DEGs) were significantly enriched in the inflammatory respo

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC5983944 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature