Integrated analysis of the gene expression profile and DNA methylation profile of obese patients with type 2 diabetes.

ABSTRACT: In order to better understand the etiology of obese type 2 diabetes (T2D) at the molecular level, the present study investigated the gene expression and DNA methylation profiles associated with T2D via systemic analysis. Gene expression (GSE64998) and DNA methylation profiles (GSE65057) from liver tissues of healthy controls and obese patients with T2D were downloaded from the Gene Expression Omnibus database. Differentially‑expressed genes (DEGs) and differentially‑methylated genes (DMGs) were identified using the Limma package, and their overlapping genes were additionally determined. Enrichment analysis was performed using the BioCloud platform on the DEGs and the overlapping genes. Using Cytoscape software, protein‑protein interaction (PPI), transcription factor target networks and mic

SUBMITTER: Shen J 

PROVIDER: S-EPMC5983955 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature