Identification of key genes in non‑alcoholic fatty liver disease progression based on bioinformatics analysis.

ABSTRACT: Due to economic development and lifestyle changes, the incidence of non‑alcoholic fatty liver disease (NAFLD) has gradually increased in recent years. However, the pathogenesis of NAFLD is not yet fully understood. To identify candidate genes that contribute to the development and progression of NAFLD, two microarray datasets were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were identified and functional enrichment analyses were performed. A protein‑protein interaction network was constructed and modules were extracted using the Search Tool for the Retrieval of Interacting Genes and Cytoscape. The enriched functions and pathways of the DEGs included 'cellular macromolecule biosynthetic process', 'cellular response to chemical stimulus', '

SUBMITTER: Li L 

PROVIDER: S-EPMC5983972 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature