Human Embryonic Stem Cell Derived from Early Stage Fertilized Ovum: Non Immunogenic and Universal, Neuronal and Non-neuronal Cell Lines.

ABSTRACT:

Background

Human embryonic stem cells (hESCs) have the potential to treat various human disorders currently labeled as incurable and/or terminal illness. However, the fear that the patients' immune system would recognize them as non self and lead to an immune rejection has hampered their use. The main cause for immune rejection is usually the incompatibility of both donor and recipient's major histocompatibility complex (MHC).

Methods

We describe a hESC line developed through a patented technology that does not lead to immune reaction upon transplantation. We have transplanted these cells in ＞1,400 patients with chronic/terminal conditions and did not observe any immune reaction. No immunosuppressant were administered to these patients. We analyzed the expression levels of M

SUBMITTER: Shroff G 

PROVIDER: S-EPMC5984064 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature