Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach.

ABSTRACT:

Background

Recently, we witnessed great progress in the discovery of genetic variants associated with obesity and type 2 diabetes (T2D), especially in adults. Much less is known regarding genetic variants associated with insulin resistance (IR). We hypothesized that novel IR genes could be efficiently detected in a population of obese children and adolescents who may not exhibit comorbidities and other confounding factors.

Objectives

This study aimed to determine whether a genome-wide association study (GWAS), using a DNA-pooling approach, could identify novel genes associated with IR.

Subjects

The pooled-DNA GWAS analysis included Slovenian obese children and adolescents with and without IR matched for body mass index, gender and age. A replication study was conducte

SUBMITTER: Kotnik P 

PROVIDER: S-EPMC5984073 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature