Global transcriptome analysis identifies weight regain-induced activation of adaptive immune responses in white adipose tissue of mice.

ABSTRACT:

Objective

Studies have indicated that weight regain following weight loss predisposes obese individuals to metabolic disorders; however, the molecular mechanism of this potential adverse effect of weight regain is not fully understood. Here we investigated global transcriptome changes and the immune response in mouse white adipose tissue caused by weight regain.

Design

We established a diet switch protocol to compare the effects of weight regain with those of weight gain without precedent weight loss, weight loss maintenance and chow diet. We conducted a time course analysis of global transcriptome changes in gonadal white adipose tissue (gWAT) during the weight fluctuation. Co-expression network analysis was used to identify functional modules associated with the weigh rega

SUBMITTER: Kyung DS 

PROVIDER: S-EPMC5984075 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature