Structural Neuroimaging and Neuropsychologic Signatures in Children With Vertically Acquired HIV.

ABSTRACT: BACKGROUND:Children with vertically acquired HIV exhibit persistent cognitive impairments, yet the corresponding neuroimaging signature of vertical infection remains unclear. METHODS:Fifty healthy control children and 51 vertically infected children were included in the study. The HIV-infected group consisted of survivors who had not received antiretroviral therapy at birth. The HIV-infected group averaged 11.4 (2.5) years of age, with a median CD4 count of 683 cells/mm(3). Most (71%) of the HIV-infected children were on antiretroviral therapy for a median of 34 months (range: 33-42) with HIV RNA <40 copies/mL in 89% of the sample. The HIV-uninfected group averaged 10.6 (2.6) years of age. Magnetic resonance imaging was acquired to determine volumes of the caudate, putamen, thalamus, palli

SUBMITTER: Paul R 

PROVIDER: S-EPMC5984109 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature