Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles.

ABSTRACT: Polypyrrole (PPy) nanoparticles (NPs) possess high near-infrared absorption and good biosafety, showing the potentials as photothermal therapeutic materials. However, the single function and the weak diagnostic function limit the further combination with other functional units to achieve theranostics. In this work, polyaminopyrrole (PPy-NH₂) is demonstrated as the alternative of PPy for preparing NPs. Because of the amino group, metal ions, such as Cu(II) and Fe(III) can be loaded in PPy-NH₂ NPs, which extends the applications in multimodal theranostics. Systematical studies reveal that the contribution of Cu(II) in multimodal theranostics is greater than Fe(III). Cu can enhance T₁ response signal for magnetic resonance imaging (MRI) and be released control

SUBMITTER: Li S 

PROVIDER: S-EPMC5984284 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature