Clinically-Applicable Perfluorocarbon-Loaded Nanoparticles For In vivo Photoacoustic, ¹⁹F Magnetic Resonance And Fluorescent Imaging.

ABSTRACT: Photoacoustic imaging (PAI) is an emerging biomedical imaging technique that is now coming to the clinic. It has a penetration depth of a few centimeters and generates useful endogenous contrast, particularly from melanin and oxy-/deoxyhemoglobin. Indocyanine green (ICG) is a Food and Drug Administration-approved contrast agents for human applications, which can be also used in PAI. It is a small molecule dye with limited applications due to its fast clearance, rapid protein binding, and bleaching effect. Methods: Here, we entrap ICG in a poly(lactic-co-glycolic acid) nanoparticles together with a perfluorocarbon (PFC) using single emulsion method. These nanoparticles and nanoparticle-loaded dendritic cells were imaged with PA, ¹⁹F MR, and fluorescence imaging i

SUBMITTER: Swider E 

PROVIDER: S-EPMC5984288 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature