Ythdf2-mediated m⁶A mRNA clearance modulates neural development in mice.

ABSTRACT:

Background

N ⁶ -methyladenosine (m⁶A) modification in mRNAs was recently shown to be dynamically regulated, indicating a pivotal role in multiple developmental processes. Most recently, it was shown that the Mettl3-Mettl14 writer complex of this mark is required for the temporal control of cortical neurogenesis. The m⁶A reader protein Ythdf2 promotes mRNA degradation by recognizing m⁶A and recruiting the mRNA decay machinery.

Results

We show that the conditional depletion of the m⁶A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. We demonstrate that neural stem/progenitor cell (NSPC) self-renewal and spatiotemporal genera

SUBMITTER: Li M 

PROVIDER: S-EPMC5984442 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature