RNA m⁶A methylation participates in regulation of postnatal development of the mouse cerebellum.

ABSTRACT:

Background

N⁶-methyladenosine (m⁶A) is an important epitranscriptomic mark with high abundance in the brain. Recently, it has been found to be involved in the regulation of memory formation and mammalian cortical neurogenesis. However, while it is now established that m⁶A methylation occurs in a spatially restricted manner, its functions in specific brain regions still await elucidation.

Results

We identify widespread and dynamic RNA m⁶A methylation in the developing mouse cerebellum and further uncover distinct features of continuous and temporal-specific m⁶A methylation across the four postnatal developmental processes. Temporal-specific m⁶A peaks from P7 to P60 exhibit remarkable changes in their distributi

SUBMITTER: Ma C 

PROVIDER: S-EPMC5984455 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature