Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans.

ABSTRACT: Malaria remains among the world's deadliest diseases, and control efforts depend critically on the availability of effective diagnostic tools, particularly for the identification of asymptomatic infections, which play a key role in disease persistence and may account for most instances of transmission but often evade detection by current screening methods. Research on humans and in animal models has shown that infection by malaria parasites elicits changes in host odors that influence vector attraction, suggesting that such changes might yield robust biomarkers of infection status. Here we present findings based on extensive collections of skin volatiles from human populations with high rates of malaria infection in Kenya. We report broad and consistent effects of malaria infection on huma

SUBMITTER: De Moraes CM 

PROVIDER: S-EPMC5984526 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature