Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain.

ABSTRACT: In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique. We investigated disease-relevant tissue changes associated with myelin loss and iron accumulation in multiple sclerosis deep gray matter (DGM) over two years. One-hundred twenty (120) multiple sclerosis patients and 40 age- and sex-matched healthy controls were included in this prospective study. Written informed consent and local IRB approval were obtained from all participants. Clinical testing and QSM were performed both at baseline and at follow-up. Brain magnetic susceptibility was measured in major DGM structures. Temporal (baseline v

SUBMITTER: Hagemeier J 

PROVIDER: S-EPMC5984575 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature