Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.

ABSTRACT:

Objectives

Expectation can significantly modulate pain and treatment effects. This study aims to investigate if boosting patients' expectancy can enhance the treatment of knee osteoarthritis (KOA), and its underlying brain mechanism.

Methods

Seventy-four KOA patients were recruited and randomized to three groups: boosted acupuncture (with a manipulation to enhance expectation), standard acupuncture, or treatment as usual (TAU). Each patient underwent six treatments before being debriefed, and four additional treatments after being debriefed. The fMRI scans were applied during the first and sixth treatment sessions.

Results

We found significantly decreased knee pain in the boosted acupuncture group compared to the standard acupuncture or TAU groups after both six and t

SUBMITTER: Kong J 

PROVIDER: S-EPMC5984593 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature