Protein disorder-order interplay to guide the growth of hierarchical mineralized structures.

ABSTRACT: A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness

SUBMITTER: Elsharkawy S 

PROVIDER: S-EPMC5984621 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature