Ontology highlight
ABSTRACT:
SUBMITTER: Hegde P
PROVIDER: S-EPMC5984626 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature communications 20180601 1
Liver fibrosis is the common response to chronic liver injury, and leads to cirrhosis and its complications. Persistent inflammation is a driving force of liver fibrosis progression. Mucosal-associated invariant T (MAIT) cells are non-conventional T cells that display altered functions during chronic inflammatory diseases. Here, we show that circulating MAIT cells are reduced in patients with alcoholic or non-alcoholic fatty liver disease-related cirrhosis while they accumulate in liver fibrotic ...[more]