Origins of Discordant Responses among 3 Rheumatoid Arthritis Improvement Criteria.

ABSTRACT:

Objective

We examined agreement between the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), and Simplified Disease Activity Index (SDAI) response criteria in rheumatoid arthritis (RA) and tested whether discordant responses were associated with patients' baseline characteristics or changes in RA activity encapsulated by the different criteria.

Methods

In a prospective longitudinal study, we examined responses of 243 patients with active RA to escalation of antirheumatic treatment. We computed agreement between pairs of response criteria using κ coefficients and identified patient characteristics associated with unique responses to individual criteria.

Results

We found that 110 patients (45.3%) had an ACR 20% improvement (ACR20) resp

SUBMITTER: Ward MM 

PROVIDER: S-EPMC5984663 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature