Stanniocalcin Expression as a Predictor of Late Breast Cancer Recurrence.

ABSTRACT: Background: Expression of human paracrine hormones stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) may potentiate late breast cancer recurrence. We tested the hypothesis that expression of STC1 and STC2 in primary breast tumors is more strongly associated with late versus early recurrences.Methods: A total of 541 estrogen receptor-positive, tamoxifen-treated (ER⁺/TAM⁺) and 300 ER-negative, tamoxifen-untreated (ER^-/TAM^-) breast cancer patients who experienced recurrence within 10 years of primary diagnosis and matched recurrence-free controls were selected from a cohort of 11,251 Danish breast cancer patients diagnosed with stage I, II, or III breast cancer during 1985 to 2001. The association between IHC expression of STC1 and STC

SUBMITTER: Brantley KD 

PROVIDER: S-EPMC5984703 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature