The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion.

ABSTRACT: Although prostate cancer is clinically manageable during several stages of progression, survival is severely compromised once cells invade and metastasize to distant organs. Comprehending the pathobiology of invasion is required for developing efficacious targeted therapies against metastasis. Based on bioinformatics data, we predicted an association of melanoma differentiation-associated gene-9 [syntenin, or syndecan binding protein (SDCBP)] in prostate cancer progression. Using tissue samples from various Gleason stage prostate cancer patients with adjacent normal tissue, a series of normal prostate and prostate cancer cell lines (with differing tumorigenic/metastatic properties), mda-9/syntenin-manipulated variants (including loss-of-function and gain-of-function cell lines), and

SUBMITTER: Das SK 

PROVIDER: S-EPMC5984708 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature