Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species.

ABSTRACT:

Background

Genome mining tools have enabled us to predict biosynthetic gene clusters that might encode compounds with valuable functions for industrial and medical applications. With the continuously increasing number of genomes sequenced, we are confronted with an overwhelming number of predicted clusters. In order to guide the effective prioritization of biosynthetic gene clusters towards finding the most promising compounds, knowledge about diversity, phylogenetic relationships and distribution patterns of biosynthetic gene clusters is necessary.

Results

Here, we provide a comprehensive analysis of the model actinobacterial genus Amycolatopsis and its potential for the production of secondary metabolites. A phylogenetic characterization, together with a pan-genome analysi

SUBMITTER: Adamek M 

PROVIDER: S-EPMC5984834 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature