A higher incidence of cleavage failure in oocytes containing smooth endoplasmic reticulum clusters.

ABSTRACT: PURPOSE:In human oocytes, sERCs are one of the dysmorphic phenotypes that have been reported. Significantly reduced pregnancy rates and a comparatively higher number of abnormities in live births appear to be associated with the presence of sERCs in oocytes. However, some reports have shown that healthy babies can be born, without any reduced pregnancy rates, from oocytes observed to contain sERCs. Thus, the clinical and scientific significance of oocytes that harbor sERCs remains controversial. METHODS:The presence of sERCs was evaluated using a time-lapse system while studying the dynamic changes within oocytes and embryos. Logistic regression analysis was carried out to explore the independent variables for meiotic and mitotic cleavage failure.. RESULTS:The incidence of mitotic cleavage

SUBMITTER: Otsuki J 

PROVIDER: S-EPMC5984874 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature