Unraveling the Motions behind Enterovirus 71 Uncoating.

ABSTRACT: Enterovirus 71 can be a severe pathogen in small children and immunocompromised adults. Virus uncoating is a critical step in the infection of the host cell; however, the mechanisms that control this process remain poorly understood. We applied normal mode analysis and perturbation response scanning to several complexes of the virus capsid and present a coarse-graining approach to analyze the full capsid. We show that our method offers an alternative to expressing the system as a set of rigid blocks and accounts for the interconnection between nodes within each subunit and protein interfaces across the capsid. In our coarse-grained approach, the modes associated with capsid expansion are captured in the first three nondegenerate modes and correspond to the changes observed in structural st

SUBMITTER: Ross CJ 

PROVIDER: S-EPMC5984953 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature