A Distribution-Moment Approximation for Coupled Dynamics of the Airway Wall and Airway Smooth Muscle.

ABSTRACT: Asthma is fundamentally a disease of airway constriction. Due to a variety of experimental challenges, the dynamics of airways are poorly understood. Of specific interest is the narrowing of the airway due to forces produced by the airway smooth muscle wrapped around each airway. The interaction between the muscle and the airway wall is crucial for the airway constriction that occurs during an asthma attack. Although cross-bridge theory is a well-studied representation of complex smooth muscle dynamics, and these dynamics can be coupled to the airway wall, this comes at significant computational cost-even for isolated airways. Because many phenomena of interest in pulmonary physiology cannot be adequately understood by studying isolated airways, this presents a significant limitation. We p

SUBMITTER: Rampadarath AK 

PROVIDER: S-EPMC5984954 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature