Detailed T1-Weighted Profiles from the Human Cortex Measured in Vivo at 3 Tesla MRI.

ABSTRACT: Studies into cortical thickness in psychiatric diseases based on T1-weighted MRI frequently report on aberrations in the cerebral cortex. Due to limitations in image resolution for studies conducted at conventional MRI field strengths (e.g. 3 Tesla (T)) this information cannot be used to establish which of the cortical layers may be implicated. Here we propose a new analysis method that computes one high-resolution average cortical profile per brain region extracting myeloarchitectural information from T1-weighted MRI scans that are routinely acquired at a conventional field strength. To assess this new method, we acquired standard T1-weighted scans at 3 T and compared them with state-of-the-art ultra-high resolution T1-weighted scans optimised for intracortical myelin contrast acquired at

SUBMITTER: Ferguson B 

PROVIDER: S-EPMC5984962 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature