Simulation of Cell Patterning Triggered by Cell Death and Differential Adhesion in Drosophila Wing.

ABSTRACT: The Drosophila wing exhibits a well-ordered cell pattern, especially along the posterior margin, where hair cells are arranged in a zigzag pattern in the lateral view. Based on an experimental result observed during metamorphosis of Drosophila, we considered that a pattern of initial cells autonomously develops to the zigzag pattern through cell differentiation, intercellular communication, and cell death (apoptosis) and performed computer simulations of a cell-based model of vertex dynamics for tissues. The model describes the epithelial tissue as a monolayer cell sheet of polyhedral cells. Their vertices move according to equations of motion, minimizing the sum total of the interfacial and elastic energies of cells. The interfacial energy densities between cells are introduced consistent

SUBMITTER: Nagai T 

PROVIDER: S-EPMC5984977 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature