Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces.

ABSTRACT: Contractile cells can reorganize fibrous extracellular matrices and form dense tracts of fibers between neighboring cells. These tracts guide the development of tubular tissue structures and provide paths for the invasion of cancer cells. Here, we studied the mechanisms of the mechanical plasticity of collagen tracts formed by contractile premalignant acinar cells and fibroblasts. Using fluorescence microscopy and second harmonic generation, we quantified the collagen densification, fiber alignment, and strains that remain within the tracts after cellular forces are abolished. We explained these observations using a theoretical fiber network model that accounts for the stretch-dependent formation of weak cross-links between nearby fibers. We tested the predictions of our model using shear

SUBMITTER: Ban E 

PROVIDER: S-EPMC5984980 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature