Deciphering the Dynamical Origin of Mixed Population during Neural Stem Cell Development.

ABSTRACT: Neural stem cells (NSCs) often give rise to a mixed population of cells during differentiation. However, the dynamical origin of these mixed states is poorly understood. In this article, our mathematical modeling study demonstrates that the bone morphogenetic protein 2 (BMP2) mediated disparate differentiation dynamics of NSCs in central and peripheral nervous systems essentially function through two distinct bistable switches that are mutually interconnected via a mushroom-like bifurcation. Stochastic simulations of the model reveal that the mixed population originates due to the existence of these bistable switching regulations and that the maintenance of such mixed states depends on the level of stochastic fluctuations of the system. It further demonstrates that due to extrinsic variabi

SUBMITTER: Sengupta D 

PROVIDER: S-EPMC5985008 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature