Amylin - Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity.

ABSTRACT: BACKGROUND:Amylin is a pancreatic β-cell hormone that produces effects in several different organ systems. One of its best-characterized effects is the reduction in eating and body weight seen in preclinical and clinical studies. Amylin activates specific receptors, a portion of which it shares with calcitonin gene-related peptide (CGRP). Amylin's role in the control of energy metabolism relates to its satiating effect, but recent data indicate that amylin may also affect hedonic aspects in the control of eating, including a reduction of the rewarding value of food. Recently, several amylin-based peptides have been characterized. Pramlintide (Symlin®) is currently the only one being used clinically to treat type 1 and type 2 diabetes. However other amylin analogs with improved pharmacokine

SUBMITTER: Boyle CN 

PROVIDER: S-EPMC5985014 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature