Cadm2 regulates body weight and energy homeostasis in mice.

ABSTRACT:

Objective

Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associations between body mass index (BMI) and multiple loci near Cell adhesion molecule2 (CADM2), which encodes a mediator of synaptic signaling enriched in the brain. Here we sought to further understand the role of Cadm2 in the pathogenesis of hyperglycemia and weight gain.

Methods

We first analyzed Cadm2 expression in the brain of both human subjects and mouse models and subsequently characterized a loss-of-function mouse model of Cadm2 for alterations in glucose and energy homeostasis.

Results

We show that the risk variant rs1

SUBMITTER: Yan X 

PROVIDER: S-EPMC5985021 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature