Effect of Grafting on Aggregation of Intrinsically Disordered Proteins.

ABSTRACT: A significant part of the proteome is composed of intrinsically disordered proteins (IDPs). These proteins do not fold into a well-defined structure and behave like ordinary polymers. In this work, we consider IDPs that have the tendency to aggregate, model them as heteropolymers that contain a small number of associating monomers, and use computer simulations to compare the aggregation of such IDPs that are grafted to a surface or free in solution. We then discuss how such grafting may affect the analysis of in vitro experiments and could also be used to suppress harmful aggregation.

SUBMITTER: Osmanovic D 

PROVIDER: S-EPMC5985032 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature