Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments.

ABSTRACT: OBJECTIVE:Obesity is a metabolic disorder that has reached epidemic proportions worldwide and leads to increased risk for diabetes, cardiovascular disease, asthma, certain cancers, and various other diseases. Obesity and its comorbidities are associated with impaired adipose tissue (AT) function. In the last decade, eosinophils have been identified as regulators of proper AT function. Our study aimed to determine whether normalizing the number of AT eosinophils in obese mice, to those of lean healthy mice, would reduce obesity and/or improve metabolic fitness. METHODS:C57BL/6J mice fed a high fat diet (HFD) were simultaneously given recombinant interleukin-5 (rIL5) for 8 weeks to increase AT eosinophils. Metabolic fitness was tested by evaluating weight gain, AT inflammation, glucose, lipi

SUBMITTER: Bolus WR 

PROVIDER: S-EPMC5985044 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature